(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → HCID 69416157, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[NH2:20][C@H:21]([C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1)[CH3:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:13]=[N:14][CH:15]=[C:16]([Cl:18])[CH:17]=2)=[C:6]([CH:10]=1)[C:7]([NH:20][C@H:21]([C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1)[CH3:22])=[O:9]참가 물질
3
실험 절차
The title compound was prepared according to the procedure described in step 3 of Example 1 from 5-chloro-2-[(5-chloropyridin-3-yl)oxy]benzoic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 3 of Example 5): 1H-NMR (CDCl3) δ 8.41 (1H, d, J=2.0 Hz), 8.28 (1H, d, J=2.5 Hz), 8.13 (1H, d, J=2.8 Hz), 7.96 (2H, d, J=8.4 Hz), 7.45 (1H, dd, J=8.7, 2.8 Hz), 7.37–7.28 (1H, m), 7.31 (2H, d, J=8.4 Hz), 7.20 (1H, dd, J=2.5, 2.0 Hz), 6.90 (1H, d, J=8.7 Hz), 5.37–5.22 (1H, m), 3.91 (3H, s), 1.51 (3H, d, J=6.9 Hz).
출처 및 근거
- ORD 기록
- ord-06bcd54ec51144c69ec3615285c0872f
- 출처 데이터셋
- uspto-grants-2007_07