2-Chlorobenzenesulfonamide → 5-Chloro-N-{(1S)-1-[4-({[(2-chlorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}-2-(4-fluorophenoxy)nicotinamide

HRID 1293271

반응식

HRID 1293271 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:16]([NH:18][C@H:19]([C:21]2[CH:29]=[CH:28][C:24]([C:25]([OH:27])=O)=[CH:23][CH:22]=2)[CH3:20])=[O:17])[C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.[Cl:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=1[S:37]([NH2:40])(=[O:39])=[O:38]>>[Cl:1][C:2]1[CH:7]=[N:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)=[C:4]([CH:3]=1)[C:16]([NH:18][C@H:19]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([NH:40][S:37]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][C:31]=2[Cl:30])(=[O:39])=[O:38])=[O:27])=[CH:23][CH:22]=1)[CH3:20])=[O:17]

참가 물질

3

반응물 2

HCID 814102-ChlorobenzenesulfonamideHCID 116830884-[(1S)-1-({[5-Chloro-2-(4-fluorophenoxy)pyridin-3-YL]carbonyl}amino)ethyl]benzoic acid

생성물 1

HCID 589053365-Chloro-N-{(1S)-1-[4-({[(2-chlorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}-2-(4-fluorophenoxy)nicotinamide

실험 절차

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 2-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.54 (1H, d, J=2.6 Hz), 8.23–8.12 (2H, m), 8.04 (1H, d, J=2.6 Hz), 7.87 (1H, d, J=7.3 Hz), 7.47–7.16 (5H, m), 7.15–7.01 (5H, m), 5.45–5.25 (1H, m), 1.48 (3H, d, J=6.4 Hz); MS (ESI) m/z 588 (M+H)+, 586 (M−H)−.

출처 및 근거

ORD 기록
ord-eb41daa66f564992ba43cabe2c32df51
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238714B2

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