4-Chlorobenzenesulfonamide → 5-Chloro-N-{(1S)-1-[4-({[(4-chlorophenyl)sulfonyl]amino}carbonyl)phenyl]ethyl}-2-(4-fluorophenoxy)nicotinamide

참여 물질

반응 단계

The title compound was prepared according to the procedure described in step 1 of Example 103 from 4-[(1S)-1-({[5-chloro-2-(4-fluorophenoxy)pyridin-3-yl]carbonyl}amino)ethyl]benzoic acid (step 5 of Example 44) and 4-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.51 (1H, d, J=2.6 Hz), 8.13 (1H, d, J=2.6 Hz), 8.16–8.03 (1H, m), 8.08 (2H, d, J=8.7 Hz), 7.75 (2H, d, J=8.2 Hz), 7.52 (2H, d, J=8.7 Hz), 7.43 (2H, d, J=8.2 Hz), 7.21–7.08 (4H, m), 5.39–5.24 (1H, m), 1.57 (3H, d, J=7.4 Hz); MS (ESI) m/z 588 (M+H)+, 586 (M−H)−.

출처 및 근거