3,5-Difluorophenol → Methyl 5-chloro-2-(3,5-difluorophenoxy)benzoate

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[F:13][C:14]1[CH:15]=[C:16]([OH:21])[CH:17]=[C:18]([F:20])[CH:19]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:21][C:16]2[CH:15]=[C:14]([F:13])[CH:19]=[C:18]([F:20])[CH:17]=2)=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

참가 물질

반응물 2

HCID 759283,5-Difluorophenol

HCID 21525433Methyl 5-chloro-2-fluorobenzoate

생성물 1

HCID 69415966Methyl 5-chloro-2-(3,5-difluorophenoxy)benzoate

실험 절차

The title compound was prepared according to the procedure described in step 1 of Example 67 from methyl 5-chloro-2-fluorobenzoate and 3,5-difluorophenol: 1H-NMR (CDCl3) δ 8.00–7.90 (1H, m), 7.55–7.47 (1H, m), 7.08–7.00 (1H, m), 6.60–6.35 (3H, m), 3.81 (3H, s).

출처 및 근거

ORD 기록: ord-049d606a86c4455a835273c7995cd696
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07238714B2

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