Benzenepropanoic acid → Methyl 3-phenylpropionate

HRID 129372

반응식

HRID 129372 반응식
[C:1]1([CH2:7][CH2:8][C:9]([OH:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[CH3:17]O>>[C:1]1([CH2:7][CH2:8][C:9]([O:11][CH3:17])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 3

HCID 107Benzenepropanoic acidHCID 887MethanolHCID 1118Sulfuric Acid

생성물 1

HCID 7643Methyl 3-phenylpropionate

실험 절차

A solution of 3-phenylpropionic acid (50 g, 0.33 mole) and conc. sulfuric acid (5 g) in methanol (220 ml) was refluxed for 1 hour with stirring, concentrated and poured into cold H2O. The mixture was extracted thrice with methylene chloride (75 ml), the organic layer was washed thrice with H2O (125 ml), dried over anhydrous MgSO4 and evaporated. The residual crude oil (54 g) was distilled under reduced pressure to give 51.5 g of methyl 3-phenylpropionate as a colorless oil having a boiling point of 94°-95° C./5 mmHg.

후처리

  1. concentrationconcentrated
  2. additionpoured into cold H2O
  3. extractionThe mixture was extracted thrice with methylene chloride (75 ml)
  4. washthe organic layer was washed thrice with H2O (125 ml)
  5. dry with materialdried over anhydrous MgSO4
  6. customevaporated
  7. distillationThe residual crude oil (54 g) was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-7856235b707843d0969564f945d077cb
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468589

연결된 노트

불러오는 중…