4-(Trifluoromethyl)phenylboronic acid → 8-Fluoro-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine

반응식

Br[C:2]1[CH:3]=[C:4]([F:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:19]=[CH:18][C:17](B(O)O)=[CH:16][CH:15]=1>>[F:11][C:4]1[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=[C:2]([C:17]2[CH:18]=[CH:19][C:14]([C:13]([F:24])([F:23])[F:12])=[CH:15][CH:16]=2)[CH:3]=1

참가 물질

반응물 2

HCID 27343894-(Trifluoromethyl)phenylboronic acid

HCID 220319336-Bromo-8-fluoroimidazo[1,2-a]pyridine

생성물 1

HCID 670001198-Fluoro-6-(4-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridine수율 100%

실험 절차

Prepared from 6-bromo-8-fluoro-imidazo[1,2-a]pyridine (example C.29 step 4) (1.5 g, 7 mmol) and commercially available 4-trifluoromethylphenylboronic acid (1.46 g, 7.7 mmol) as described in example C.20 step 2. Obtained the title compound as a light brown solid (1.95 g, 100%). MS (ISP) 281.1 [(M+H)+].

출처 및 근거

ORD 기록: ord-d23f04852cff4991b886f7ea8df7707e
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07238808B2

반응 노트

불러오는 중…