Methylamine → 3-amino-N,3-dimethylbutanamide

반응식

Cl.[NH2:2][C:3]([CH3:10])([CH3:9])[CH2:4][C:5](OC)=[O:6].[CH3:11][NH2:12]>>[CH3:11][NH:12][C:5](=[O:6])[CH2:4][C:3]([NH2:2])([CH3:10])[CH3:9]

참가 물질

반응물 2

HCID 6329Methylamine

HCID 19371621Methyl 3-amino-3-methylbutanoate hydrochloride

생성물 1

HCID 177971033-amino-N,3-dimethylbutanamide

실험 절차

A mixture of methyl 3-amino-3-methyl-butyrate hydrochloride (10.5 g; 62.6 mmoles) and methyl amine (33% solution in ethanol; 55 ml) is refluxed for 18 hours. The solvent is evaporated, the crude is dissolved in methylene chloride (100 ml) and washed with a saturate aqueous solution of sodium chloride (10 ml). After drying over sodium sulphate and evaporation of the solvent to dryness, N-methyl-3-amino-3-methyl-butyramide is obtained; chromatographically pure colorless oil (T.L.C., eluent--methylene chloride:methanol:NH4OH=80:15:1)

후처리

temperatureis refluxed for 18 hours
customThe solvent is evaporated
dissolutionthe crude is dissolved in methylene chloride (100 ml)
washwashed with a saturate aqueous solution of sodium chloride (10 ml)
dry with materialAfter drying over sodium sulphate and evaporation of the solvent to dryness

출처 및 근거

ORD 기록: ord-fa49d532d27545ccb08172229df5e489
출처 데이터셋: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05468746

반응 노트

불러오는 중…