Methyl 2-(2-benzyloxy-5-ethoxyphenyl)acetate → Methyl 2-(5-ethoxy-2-hydroxyphenyl)acetate

HRID 1294130노트

반응식

HRID 1294130 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH3:17])=[CH:11][C:10]=1[CH2:18][C:19]([O:21][CH3:22])=[O:20])C1C=CC=CC=1>[C].[Pd].O1CCCC1>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH3:17])=[CH:11][C:10]=1[CH2:18][C:19]([O:21][CH3:22])=[O:20]

참가 물질

4

반응물 1

HCID 17861303Methyl 2-(2-benzyloxy-5-ethoxyphenyl)acetate

생성물 1

HCID 17861247Methyl 2-(5-ethoxy-2-hydroxyphenyl)acetate수율 73.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of methyl 2-(2-benzyloxy-5-ethoxyphenyl)acetate (1.60 g), 5% palladium carbon (3.0 g) and tetrahydrofuran (50 mL) was subjected to catalytic hydrogenation at room temperature and 1 atm. After filtering off the catalyst, the solvent was evaporated under reduced pressure. Hexane was added to the obtained crystals and the mixture was filtrated to give crystals (0.82 g) of methyl 2-(2-hydroxy-5-ethoxyphenyl)acetate. Recrystallization from diisopropyl ether-hexane gave pale-yellow prism crystals. melting point: 83-84° C.

후처리

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationAfter filtering off the catalyst
  3. customthe solvent was evaporated under reduced pressure
  4. additionHexane was added to the obtained crystals
  5. filtrationthe mixture was filtrated

출처 및 근거

ORD 기록
ord-494d51de0a744ba9b3ea26724663883b
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238716B2

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