Thionyl Chloride → 4-Chloromethyl-2-phenyl-5-propyloxazole

HRID 1294162노트

반응식

HRID 1294162 반응식
[C:1]1([C:7]2[O:8][C:9]([CH2:14][CH2:15][CH3:16])=[C:10]([CH2:12]O)[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:19])=O>C1(C)C=CC=CC=1>[Cl:19][CH2:12][C:10]1[N:11]=[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[O:8][C:9]=1[CH2:14][CH2:15][CH3:16]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 178612102-Phenyl-5-propyl-4-oxazolylmethanol

생성물 1

HCID 178613954-Chloromethyl-2-phenyl-5-propyloxazole수율 151%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a mixture of 2-phenyl-5-propyl-4-oxazolylmethanol (1.38 g) and toluene (100 mL) was added thionyl chloride (1.38 g) under ice-cooling, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The mixture was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 4-chloromethyl-2-phenyl-5-propyloxazole as a colorless oil (2.26 g, 99%).

후처리

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washThe mixture was washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-45e9cf638f1847c484d57469216781e0
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238716B2

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