Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 129419생성일: 2026년 10월 27일
Trimethyl((tributylstannyl)ethynyl)silane → Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-(trimethylsilylethinyl)-4-oxo-3-quinolinecarboxylate
https://huagongshe.com/reaction/129419
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Trimethyl((tributylstannyl)ethynyl)silane | HCID 639663 | — |
| 반응물 | Ethyl 8-chloro-1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 13579166 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-(trimethylsilylethinyl)-4-oxo-3-quinolinecarboxylate | HCID 19371458 | 38% |
반응 단계
1.64 g of ethyl 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate, 3 g of tributylstannyl-trimethylsilyl-acetylene and 0.29 g of tetrakis(triphenylphosphine)palladium(0) are refluxed for 42 hours in 20 ml of absolute toluene under a nitrogen atmosphere. The reaction mixture is cooled to approx. -18° C. and filtered. After the filter residue has been dried, 0.74 g of ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-(trimethylsilylethinyl)-4-oxo-3-quinolinecarboxylate is obtained (38% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05468742 |
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| 출처 데이터셋 | uspto-grants-1995_11 |
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| ORD ID | ord-76f4145bd2584731a1b174ab5961ad22 |
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| 출처 메모 | uspto-grants-1995_11 |
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