Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → trans-1-Benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | trans-1-Benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine | HCID 67598706 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | trans-1-Benzoyl-3-bromo-4-(2-tosyloxyethoxy)-pyrrolidine | HCID 86748810 | — |
반응 단계
92 g (0,239 mol) of trans-1-benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine, 32 g (0.316 mol) of triethylamine, and 1 g of 4-dimethylaminopyridine are dissolved in 750 ml of toluene. 60 g (0.31 mol) of tosyl chloride in 450 ml of toluene are added dropwise. The batch is stirred two days at room temperature, water is added, and the aqueous phase separated and extracted with toluene. The toluene solutions are washed with 10% hydrochloric acid, dried over magnesium sulfate, concentrated, dissolved in ethyl acetate, and filtered through silica gel. The filtrate is concentrated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05468742 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-de50d233c30d4834a316e8d12f24762f |
| 출처 메모 | uspto-grants-1995_11 |