Formaldehyde → HCID 69433836, 화합물

HRID 1294453노트

반응식

HRID 1294453 반응식
Cl.[C:2]([C:4]1[CH:12]=[CH:11][C:7]([CH2:8][O:9][NH2:10])=[C:6]([O:13][CH2:14][CH3:15])[CH:5]=1)#[N:3].[CH3:16][OH:17].C=O>O>[C:2]([C:4]1[CH:12]=[CH:11][C:7]([CH2:8][O:9][NH2:10])=[C:6]([O:13][CH2:14][CH3:15])[CH:5]=1)#[N:3].[CH2:16]=[O:17]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 887MethanolHCID 69434226O-(4-cyano-2-ethoxybenzyl)hydroxyamine hydrochloride

생성물 1

HCID 69433836HCID 69433836, 화합물수율 96%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

O-(4-cyano-2-ethoxybenzyl)hydroxyamine hydrochloride (19-1, 2.7 g, 0.012 mol), methanol (20 ml) and water (20 ml) were charged, and a 36% formaldehyde aqueous solution was added to this, and the mixture was stirred at room temperature for 2.0 hours. Water was added to the mixture and the mixture was extracted with ethyl acetate. The resulted ethyl acetate layer was dried over anhydrous magnesium sulfate, then, the solvent was distilled off under reduce pressure. This was purified by silica gel column chromatography using hexane/ethyl acetate system, to obtain O-(4-cyano-2-ethoxybenzyl)hydroxyamine-formaldehyde derivative (3-1a, 2.2 g, yield 96%).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe resulted ethyl acetate layer was dried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off
  4. customThis was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-b635086fdb4b4c5d979b53b05dc73ddb
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241625B2

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