Anthranilic Acid → Isopropyl anthranilate

HRID 1294561노트

반응식

HRID 1294561 반응식
[C:1]([OH:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].S(Cl)(Cl)=O.[CH3:15][CH:16](O)[CH3:17]>>[NH2:4][C:3]1[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=1[C:1]([O:10][CH:16]([CH3:17])[CH3:15])=[O:9]

참가 물질

4

반응물 3

HCID 227Anthranilic AcidHCID 3776IsopropanolHCID 24386Thionyl Chloride2회

생성물 1

HCID 87499Isopropyl anthranilate

실험 절차

1.0 g (7.3 mmol) anthranilic acid are dissolved in 5 ml propan-2-ol, combined with 795 μl (10.9 mmol) thionyl chloride and refluxed for 3 days. Then thionyl chloride is eliminated in vacuo, the residue is taken up in 50 ml dist. water and extracted three times with 30 ml of ethyl acetate. The organic phase is washed with 20 ml of a saturated aqueous NaHCO3 solution, dried with MgSO4 and the solvent is eliminated in vacuo.

후처리

  1. temperaturerefluxed for 3 days
  2. extractionwater and extracted three times with 30 ml of ethyl acetate
  3. washThe organic phase is washed with 20 ml of a saturated aqueous NaHCO3 solution
  4. dry with materialdried with MgSO4

출처 및 근거

ORD 기록
ord-ebc38455508b4e25a78d9749207a0db0
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241769B2

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