Hydrazine → 2-(Furan-2-yl)aniline

HRID 1294571

반응식

HRID 1294571 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)([O-])=O.NN>C(O)C.[Pd]>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[NH2:1]

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 123772252-(2-Nitrophenyl)furan

생성물 1

HCID 46853502-(Furan-2-yl)aniline

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

113 mg (0.6 mmol) 2-(2-nitro-phenyl)-furan are dissolved in 2 ml of ethanol and combined with 6 mg palladium on activated charcoal (10% Pd). 110 μl of a 35% aqueous hydrazine solution are added to this suspension and the reaction mixture is stirred for 20 h under reflux conditions. The catalyst is suction filtered, the filtrate is combined with 25 ml of water and adjusted to pH 5. This mixture is extracted three times with 10 ml of ethyl acetate. The combined organic phases are dried and the solvent is eliminated in vacuo.

후처리

  1. filtrationfiltered
  2. extractionThis mixture is extracted three times with 10 ml of ethyl acetate
  3. customThe combined organic phases are dried

출처 및 근거

ORD 기록
ord-5c9fa89d29a94b56a8b230fd8def624a
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241769B2

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