Stannous chloride dihydrate → 1-[2-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-4-ethylbenzoyl]-piperidine

참여 물질

반응 단계

To a stirred solution of 2-nitro-4-vinylbenzoic acid piperidine amide (100 mg, 0.39 mmol) in methanol (15 mL) was added Pd on carbon (10 wt %, 25 mg). The reaction mixture was maintained under ˜1 atm H2 and stirred for 12 h. The mixture was filtered through diatomaceous earth and concentrated in vacuo to yield (4-ethyl-2-nitro-phenyl)-piperidin-1-yl-methanone, which was subsequently reduced to (2-amino-4-ethyl-phenyl)-piperidin-1-yl-methanone with SnCl2.2H2O as described in EXAMPLE 5. The title compound was prepared from the aniline (90 mg, 0.39 mmol) and 4-chlorosulfonyl-2,1,3-benzothiadiazole (181 mg, 0.78 mmol), and purified as described in EXAMPLE 15 TLC (silica gel, 3:1 EtOAc/hexanes): Rf=0.32. MS (ESI): m/z 431 [M+H]+, 453 [M+Na]+. HPLC (reversed-phase): RT=9.52 min (single peak). 1H NMR (400 MHz, CDCl3): (rotameric broadening) 8.95 (s, 1H), 8.21 (m, 2H), 7.65 (dd, J=8.8, 7 Hz, 1H), 7.47 (d, J=1.3 Hz, 1H), 6.95 (d, J=7.8 Hz, 1H), 6.85 (dd, J=7.9, 1.6 Hz, 1H), 3.14 (bs, 4H), 2.60 (m, 2H), 1.61 (m, 2H), 1.43 (bs, 4H), 1.17 (t, J=7.6 Hz, 3H). Elemental analysis: calculated for C20H22N4O3S2, C, 55.79; H, 5.15; N, 13.01; found C, 55.44; H, 5.50; N, 12.62.

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