Ethyl Acetate → [4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl)-methanone

HRID 1294811노트

반응식

HRID 1294811 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH:7]=[CH:6]2.[CH:19]1([CH2:22][O:23][C:24]2[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:29][C:25]=2[C:26](O)=[O:27])[CH2:21][CH2:20]1.C(OCC)(=O)C>C(#N)C>[Cl:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([N:13]1[CH2:14][CH2:15][N:16]([C:26]([C:25]3[CH:29]=[C:30]([S:33]([CH3:36])(=[O:35])=[O:34])[CH:31]=[CH:32][C:24]=3[O:23][CH2:22][CH:19]3[CH2:21][CH2:20]3)=[O:27])[CH2:17][CH2:18]1)[CH:7]=[CH:6]2

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 211002282-Cyclopropylmethoxy-5-methanesulfonyl-benzoic acidHCID 688966846-Chloro-2-piperazin-1-yl-quinoline hydrochloride

생성물 1

HCID 58906304[4-(6-Chloro-quinolin-2-yl)-piperazin-1-yl]-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl)-methanone

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Prepared in analogy to example 1.1 b) from 6-chloro-2-piperazin-1-yl-quinoline hydrochloride (Example 1.20b) and 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (Example 2.6) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid. MS (m/e): 500.3 (M+H+; 100%)

출처 및 근거

ORD 기록
ord-39f4022162a248bdbcd8d06f47332da8
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241761B2

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