Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydroxybenzaldehyde → 4-Piperidin-1-ylmethyl-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydroxybenzaldehyde | HCID 126 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-Piperidin-1-ylmethyl-phenol | HCID 11636972 | — |
반응 단계
A solution of 4-hydroxybenzaldehyde (10 g), piperidine (8.9 mL), and acetic acid (4.7 mL) in DCE (200 mL) was treated with sodium triacetoxyborohydride (24 g). After 16 h, the resulting mixture was treated with saturated aqueous sodium bicarbonate (100 mL) and extracted with DCM (5×100 mL). The combined organic phases were dried (magnesium sulfate) and evaporated. Trituration of the residue with ethyl acetate gave the title compound as a white crystalline solid (5.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07241778B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-369469c825b844889544656088798438 |
| 출처 메모 | uspto-grants-2007_07 |