2,3-difluoro-N-methoxy-N-methylbenzamide → (2,3-Difluorophenyl)(4-methoxyphenyl)methanone

반응식

[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[CH:19][CH:18]=1>>[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[O:5]

참가 물질

반응물 2

HCID 626611902,3-difluoro-N-methoxy-N-methylbenzamide

HCID 178491912HCID 178491912, 화합물

생성물 1

HCID 62650974(2,3-Difluorophenyl)(4-methoxyphenyl)methanone

실험 절차

Prepared according to Method A step B from 2,3-difluoro-N-methoxy-N-methylbenzamide (3.0 g, 15 mmol) and 4-methoxyphenylmagnesium bromide (35 mL, 0.5 M in THF) to give 1.44 g of the title compound as a white solid.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-6670d87a97704d5faff159be8a326f6a
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241791B2

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