2,3-difluoro-N-methoxy-N-methylbenzamide → (2,3-Difluorophenyl)(4-methoxy-2-methylphenyl)methanone

HRID 1294867노트

반응식

HRID 1294867 반응식
[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[C:19]([CH3:25])[CH:18]=1>>[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][C:19]=1[CH3:25])=[O:5]

참가 물질

3

반응물 2

HCID 626611902,3-difluoro-N-methoxy-N-methylbenzamideHCID 178491917HCID 178491917, 화합물

생성물 1

HCID 68884896(2,3-Difluorophenyl)(4-methoxy-2-methylphenyl)methanone

실험 절차

Prepared according to Method A step B from 2,3-difluoro-N-methoxy-N-methyl-benzamide (3.77 g, 18.7 mmol) and 4-methoxy-2-methyl-phenylmagnesium bromide (49 mL, 0.5 M in THF) to give 1.45 g of the title compound as a white solid.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-e104e33c282b4f04ab0907bd5ac6b9a0
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241791B2

반응 노트

불러오는 중…