3-chloro-2-fluoro-N-methoxy-N-methylbenzamide → (3-Chloro-2-fluorophenyl)(2,4-dimethoxyphenyl)methanone

반응식

[F:1][C:2]1[C:13]([Cl:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[Mg]Br>>[Cl:14][C:13]1[C:2]([F:1])=[C:3]([C:4]([C:20]2[CH:19]=[CH:18][C:17]([O:16][CH3:15])=[CH:22][C:21]=2[O:23][CH3:24])=[O:5])[CH:10]=[CH:11][CH:12]=1

참가 물질

반응물 2

HCID 114700033-chloro-2-fluoro-N-methoxy-N-methylbenzamide

HCID 178491918HCID 178491918, 화합물

생성물 1

HCID 64713965(3-Chloro-2-fluorophenyl)(2,4-dimethoxyphenyl)methanone

실험 절차

Prepared according to Method A step B from 2-fluoro-3-chloro-N-methoxy-N-methyl-benzamide (2.44 g, 11.2 mmol) and 2,4-dimethoxyphenylmagnesium bromide (20 mL, 0.5 M in THF) to give 0.95 g of the title compound as a white solid.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-4c3f0f417fa6450e924c4307967767aa
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241791B2

반응 노트

불러오는 중…