2,2',4,4'-Tetrahydroxybenzophenone → 4-(1-butyl-6-hydroxy-1H-indazol-3-yl)benzene-1,3-diol

반응식

O[C:2]1[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[OH:13])=O.C([O-])(=O)C.[Na+].C(O)(=O)C(O)=O.[CH2:30]([NH:34][NH2:35])[CH2:31][CH2:32][CH3:33]>>[CH2:30]([N:34]1[C:2]2[C:3](=[CH:14][CH:15]=[C:16]([OH:18])[CH:17]=2)[C:4]([C:6]2[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=2[OH:13])=[N:35]1)[CH2:31][CH2:32][CH3:33]

참가 물질

반응물 3

HCID 85712,2',4,4'-Tetrahydroxybenzophenone

HCID 162021Butylhydrazine oxalate

HCID 517045Sodium Acetate

생성물 1

HCID 1355245104-(1-butyl-6-hydroxy-1H-indazol-3-yl)benzene-1,3-diol수율 38.9%

실험 절차

Prepared according to Method B from 2,2′,4,4′-tetrahydroxybenzophenone (0.123 g, 0.5 mmol), sodium acetate (0.164 g, 2 mmol) and butylhydrazine oxalate (0.178 g, 1.0 mmol) to give 0.058 g of product as a pink solid

후처리

customPrepared

출처 및 근거

ORD 기록: ord-ff78383cee8f40bc946ca603d0b5263f
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241791B2

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