Cyclohexene → 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol

HRID 1294963노트

반응식

HRID 1294963 반응식
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[F:15])[C:8]([C:16]3[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688843061-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-1H-indazole

생성물 1

HCID 1355248674-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol수율 46.1%

실험 절차

Prepared according to Method D step C from 1-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-1H-indazole (0.57 g, 1.83 mmol), boron tribromide (0.70 mL, 7.35 mmol) and 3 mL of cyclohexene to give the product (0.25 g) as a white solid.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-4e52ee9e55e04aa699672878c4e6ac82
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241791B2

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