HCID 69069452, 화합물 → HCID 69061805, 화합물

반응식

[CH:1]1([CH2:4][CH:5]=[CH:6][CH2:7][CH2:8][CH:9]2[CH2:13][O:12]C(C)(C)[O:10]2)[CH2:3][CH2:2]1>CC(O)=O>[CH:1]1([CH2:4][CH:5]=[CH:6][CH2:7][CH2:8][CH:9]([OH:10])[CH2:13][OH:12])[CH2:2][CH2:3]1

참가 물질

실험 절차

Stirred 4-(5-Cyclopropyl-pent-3-enyl)-2,2-dimethyl-[1,3]dioxolane (0.30 g, 1.4 mmol) in 80% AcOH (5 mL) overnight at room temperature. Concentrated and purified by silica gel chromatography (70˜90% EtOAc in hexanes) to collect 7-Cyclopropyl-hept-5-ene-1,2-diol as a clear oil. 1H NMR (400 MHz, CDCl3): δ 5.52–5.47 (m, 1H), 5.41–5.35 (m, 1H), 3.77–3.71 (m, 1H), 3.66 (d, 1H, J=11.2 Hz), 3.46 (dd, 1H, J1=11.2 Hz, J2=7.7 Hz), 2.19–2.10 (m, 2H), 1.97 (t, 2H, J=7.1 Hz), 1.53–1.46 (m, 2H), 0.74–0.68 (m, 1H), 0.44–0.39 (m, 2H), 0.08–0.04(m, 2H).

후처리

concentrationConcentrated
custompurified by silica gel chromatography (70˜90% EtOAc in hexanes)
customto collect 7-Cyclopropyl-hept-5-ene-1,2-diol as a clear oil

출처 및 근거

ORD 기록: ord-0adba13d7e6b4744bd5d326a121acf49
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241792B2

반응 노트

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참가 물질

반응물 1

HCID 69069452HCID 69069452, 화합물

생성물 1

HCID 69061805HCID 69061805, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

후처리

concentrationConcentrated
custompurified by silica gel chromatography (70˜90% EtOAc in hexanes)
customto collect 7-Cyclopropyl-hept-5-ene-1,2-diol as a clear oil

출처 및 근거

ORD 기록: ord-0adba13d7e6b4744bd5d326a121acf49
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241792B2

반응 노트

불러오는 중…