HCID 22570297, 화합물 → Methyl 3-(5-hydroxyindolyl)-2-methylpropanoate

HRID 1295116노트

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HRID 1295116 반응식
[CH3:1][CH:2]([CH2:7][C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([O:17]CC1C=CC=CC=1)=[CH:12][CH:11]=2)[C:3]([O:5][CH3:6])=[O:4]>C(O)C.[Pd]>[OH:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([CH2:7][CH:2]([CH3:1])[C:3]([O:5][CH3:6])=[O:4])=[CH:16]2

참가 물질

4

반응물 1

HCID 22570297HCID 22570297, 화합물

생성물 1

HCID 22570322Methyl 3-(5-hydroxyindolyl)-2-methylpropanoate수율 85%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of methyl 2-methyl-3-[5-benzyloxyindolyl]propanoate (0.18 g, 0.56 mmol), as prepared in the preceding step, 10% palladium(0) on carbon (0.018 g) in ethanol (10 mL) was stirred at ambient temperature under hydrogen (balloon) overnight (16 h). The catalyst was removed by filtration through Celite. The filtrate was concentrated to give the title compound as a light brown oil (0.11 g, 85%) which was used directly in the next reaction.

후처리

  1. customThe catalyst was removed by filtration through Celite
  2. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-5053926935a34cf8afad0bbb8c7dee8e
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241789B2

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