HCID 69424243, 화합물 → Sri 62320

HRID 1295200

반응식

HRID 1295200 반응식
[Na+:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:18]([CH3:20])[CH3:19])[C:10]=2[CH2:21][CH2:22][CH:23]([OH:31])[CH2:24][C:25]([OH:30])=[CH:26][C:27]([O-:29])=[O:28])=[CH:5][CH:4]=1>C(O)C>[CH3:20][CH:18]([N:11]1[C:10](/[CH:21]=[CH:22]/[C@@H:23]([OH:31])[CH2:24][C@@H:25]([OH:30])[CH2:26][C:27]([O-:29])=[O:28])=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([F:2])=[CH:4][CH:5]=2)[C:17]2[C:12]1=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH3:19].[Na+:1]

참가 물질

3

반응물 1

HCID 69424243HCID 69424243, 화합물

생성물 1

HCID 23663976Sri 62320수율 70%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2 g of fluvastatin sodium (prepared according to Example 8 of U.S. Pat. No. 4,739,073 and Example 14D of U.S. Pat. No. 5,354,772 A) heated to boiling in 35 ml of ethanol until the material goes into solution. The hot solution obtained is filtered into 80 ml of boiling 2-propanol and allowed to cool to room temperature, while the precipitation of the anhydrous amorphous form of fluvastatin sodium salt begins. The suspension obtained is allowed to stand at 40° C. for 4 hours, and then filtered, washed with cold ethanol (4° C.) and dried in vacuum at room temperature. Thus 1.4 g of anhydrous amorphous fluvastatin sodium salt is obtained (yield 70%). X-ray powder diffraction examination (FIG. 3 as shown in the accompanied drawings) confirmed the amorphous nature of the product.

후처리

  1. temperature5,354,772 A) heated
  2. customThe hot solution obtained
  3. filtrationis filtered into 80 ml of boiling 2-propanol
  4. customThe suspension obtained
  5. filtrationfiltered
  6. washwashed with cold ethanol (4° C.)
  7. customdried in vacuum at room temperature

출처 및 근거

ORD 기록
ord-a5c529b99bde4fbfb42b39db495e927a
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241800B2

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