(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol → HCID 22930766, 화합물

HRID 1295276노트

반응식

HRID 1295276 반응식
[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH:14]=[O:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 22930692(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol

생성물 1

HCID 22930766HCID 22930766, 화합물수율 91%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of (3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol (11.20 g), active manganese dioxide (30.00 g) and tetrahydrofuran (300 ml) was stirred overnight at room temperature. Insoluble material was filtered off and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and 3-benzyloxy-1-phenyl-1H-pyrazole-5-carbaldehyde (10.10 g, yield 91%) was obtained as a pale-yellow oil from a fraction eluted with ethyl acetate-hexane (1:2, volume ratio).

후처리

  1. filtrationInsoluble material was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-152ec01c6cf24cde9281a8f9051a98cd
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241785B2

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