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4-Nitrophenyl chloroformate → 4-Nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride

HRID 1295431
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HRID 1295431 반응식
[Cl:1]C1C=C2C(=C(Cl)C=1)CN(C)CC2C1C=C(N)C=CC=1.[Cl:21][C:22]1[CH:23]=[C:24]2[C:29](=[C:30]([Cl:32])[CH:31]=1)[CH2:28][N:27]([CH3:33])[CH2:26][CH:25]2[C:34]1[CH:35]=[C:36]([NH:40][C:41](=[O:52])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[CH:37]=[CH:38][CH:39]=1.ClC1C=C2C(=C(Cl)C=1)CN(C)CC2C1C=CC([C@@](O)([C@@H](O)[C@H](O)[C@H](O)CO)C(N)=O)=CC=1.ClC([O:88][C:89]1[CH:94]=[CH:93][C:92]([N+:95]([O-:97])=[O:96])=[CH:91][CH:90]=1)=O>ClCCl>[ClH:1].[Cl:21][C:22]1[CH:23]=[C:24]2[C:29](=[C:30]([Cl:32])[CH:31]=1)[CH2:28][N:27]([CH3:33])[CH2:26][CH:25]2[C:34]1[CH:35]=[C:36]([NH:40][C:41](=[O:52])[O:88][C:89]2[CH:94]=[CH:93][C:92]([N+:95]([O-:97])=[O:96])=[CH:91][CH:90]=2)[CH:37]=[CH:38][CH:39]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 821294-Nitrophenyl chloroformate2회HCID 98361943-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)anilineHCID 11213884N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamideHCID 69511913[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanamide

생성물 1

HCID 22386892
4-Nitrophenyl [3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]carbamate hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

350 mg (1.1 mmol) of 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (Example compound 2, intermediate 1) were dissolved in 17.5 ml of dichloromethane and admixed with stirring with 230 mg (1.1 mmol) of 4-nitrophenyl chloroformate. After 4.5 hours, a further 0.1 equivalent (23 mg) of 4-nitrophenyl chloroformate was added and the solution was stirred overnight. For workup, the resulting precipitate was filtered off and washed with dichloromethane. The crude product obtained in this way could be reacted further without further purification.

후처리

  1. filtrationFor workup, the resulting precipitate was filtered off
  2. washwashed with dichloromethane

출처 및 근거

ORD 기록
ord-3fb6f50621124956a0f1f53efef6829b
출처 데이터셋
uspto-grants-2007_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07241775B2

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