Ammonium Hydroxide → 6-Iodoquinolin-2-amine

반응식

Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([I:12])[CH:8]=2)[N:3]=1.[OH-].[NH4+:14]>>[I:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([NH2:14])[CH:11]=[CH:10]2

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 198986972-Chloro-6-iodo-quinoline

생성물 1

HCID 589078666-Iodoquinolin-2-amine수율 84%

반응 조건

온도: 140 °C

실험 절차

A suspension of 2-chloro-6-iodo-quinoline (1 g, 3.46 mmol) in ammonium hydroxide (28%, 20 mL) was heated at 140° C. for 3 days under pressure tube. After cooling, the solvent was removed by rotary evaporator. The solid was collected by filtration, washed with water and dried to obtain 6-iodo-quinolin-2-ylamine (0.78 g, 84%) as a black solid. LC-MS m/e 271 (MH+).

후처리

temperatureAfter cooling
customthe solvent was removed by rotary evaporator
filtrationThe solid was collected by filtration
washwashed with water
customdried

출처 및 근거

ORD 기록: ord-87a922d782d44d1ca0046e31f953c470
출처 데이터셋: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07241893B2

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