Nitric Acid → HCID 17965148, 화합물
반응식
[N+:1]([O-:4])(O)=[O:2].[NH:5]1[CH2:10][CH2:9][CH:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH2:7][CH2:6]1>C(O)(=O)C>[N+:1]([C:16]1[CH:17]=[C:12]([CH2:11][CH:8]2[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]2)[CH:13]=[CH:14][C:15]=1[OH:18])([O-:4])=[O:2]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
Concentrated nitric acid in acetic acid (8 mL 70% HNO3 aq in 16 mL acetic acid) was added slowly to a stirred solution of 4-(piperidin-4-ylmethyl)phenol (Guzikowski et al, J. Med Chem., 2000, 43, 984–994) (100 mmol) in acetic acid (300 mL) and the resultant slurry stirred at 80° C. for 1 h. The reaction mixture was then filtered and evaporated in vacuo to give the title compound as a brown solid.
후처리
- filtrationThe reaction mixture was then filtered
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-a905c7a4759a42a1a7c78e739e061e0e
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07244726B2
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