Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Chloride → 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | 1,4-Butanediol | HCID 8064 | — |
| 반응물 | 1,2,4,5-Tetrafluorobenzene | HCID 9474 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(2,4,5-Trifluoro-phenoxy)butan-1-ol | HCID 69364663 | — |
반응 단계
To a mixture of 1,4-butanediol (15 g, 0.17 mol) and t-BuOK (8.0 g, 0.071 mol) were added 1,2,4,5-tetrafluorobenzene (5.0 g, 33 mmol) and DMSO (50 g) at 60° C. After being stirred at this temperature for 18 h, toluene (200 mL), water (50 mL) and sodium chloride (10 g) were added to the reaction mixture. The layers were separated and the organic layer was concentrated in vacuo giving the title compound. This material was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07244722B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-663d6016ba36490f8673a3c4952bbb51 |
| 출처 메모 | uspto-grants-2007_07 |