Ammonia → 114812-34-9

HRID 129574노트

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HRID 129574 반응식
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([O:10]CC)=O)[CH3:2].[NH3:13]>CO>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([NH2:13])=[O:10])[CH3:2]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 10942897Ethyl (S)-(-)-1-Ethyl-2-pyrrolidinecarboxylate

생성물 1

HCID 10866443114812-34-9

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

Ethyl (-)-(S)-1-ethyl-2-pyrrolidinecarboxylate (3.4 g, 0.02 mol) was added to a cooled solution of MeOH (10 ml) and liquid NH3 (10 ml) in a stainless steel reaction bottle containing 3 g of 3 A molecular sieves. The bottle was heated at 50° C. for 20 h. After cooling the solvent was allowed to evaporate. The product was dissolved in dry MeOH, filtered and the filtrate was evaporated under reduced pressure to give the title compound as white crystals in a quantitative yield (2.8 g).

후처리

  1. temperatureAfter cooling the solvent
  2. customto evaporate
  3. dissolutionThe product was dissolved in dry MeOH
  4. filtrationfiltered
  5. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7c33fdd0a3dd4474ac38d60444b2d4a3
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468876

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