Water → (2-Oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate

HRID 1295816노트

반응식

HRID 1295816 반응식
[OH:1][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11].C(N(CC)CC)C.[CH2:19]([N:21]([CH2:25][CH3:26])[C:22](Cl)=[O:23])[CH3:20].O>ClCCl>[CH2:19]([N:21]([CH2:25][CH3:26])[C:22](=[O:23])[O:1][CH2:2][N:3]1[CH2:7][CH:6]([CH2:8][CH2:9][CH3:10])[CH2:5][C:4]1=[O:11])[CH3:20]

참가 물질

6

반응물 4

HCID 962WaterHCID 6916Diethylcarbamoyl chlorideHCID 8471TriethylamineHCID 113326021-(Hydroxymethyl)-4-propylpyrrolidin-2-one

생성물 1

HCID 11448237(2-Oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate

시약·촉매·용매 1

HCID 6344Dichloromethane용매3회

실험 절차

To a solution of 1-(hydroxymethyl)-4-propyl-pyrrolidin-2-one a24 (4 g, 25.44 mmol) and triethylamine (1.2 eq, 30.53 mmol, 3.089 g; 4.26 ml) in 25 ml of dichloromethane was added dropwise a solution of diethylcarbamyl choride (1.1 eq, 27.99 mmol, 3.795 g, 3.55 ml) in dichloromethane (5 ml) at room temperature. The crude mixture was allowed to react under agitation and inert atmosphere overnight. Hydrolysis (15 ml of water), extraction (CH2Cl2), drying of the combinated organic layers (MgSO4), filtration and solvent evaporation under reduced pressure gave (2-oxo-4-propylpyrrolidin-1-yl)methyl diethylcarbamate a26 (100%) which was used without any further purification.

후처리

  1. customto react under agitation and inert atmosphere overnight
  2. dry with materialdrying of the combinated organic layers (MgSO4), filtration and solvent evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-45e4ba8aba6b4dfc97a9ebe6b94f1f4e
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244747B2

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