Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Cyanophenylboronic acid → (3aR,6aR)-5-methyl-1-(4'-pyrimidin-5-yl-1,1'-biphenyl-4-yl)octahydropyrrolo[3,4-b]pyrrole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Cyanophenylboronic acid | HCID 2734326 | — |
| 반응물 | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| 반응물 | (3aR,6aR)-1-(4-Bromophenyl)-5-methyloctahydropyrrolo[3,4-b]pyrrole | HCID 44221503 | — |
| 생성물 | (3aR,6aR)-5-methyl-1-(4'-pyrimidin-5-yl-1,1'-biphenyl-4-yl)octahydropyrrolo[3,4-b]pyrrole | HCID 24743650 | — |
반응 단계
The title compound was prepared according to the procedure described in Example 7D, substituting the product of Example 41A for the product of Example 7C and substituting pyrimidine-5-boronic acid for 4-cyanophenylboronic acid. 1H NMR (300 MHz, CDCl3) δ ppm 9.19 (s, 1H) 8.99 (s, 2H) 7.62-7.74 (m, 4H) 7.52-7.58 (m, 2H) 6.63-6.70 (m, 2H) 4.20-4.31 (m, 1H) 3.55-3.67 (m, 1H) 3.30-3.42 (m, 1H) 2.99-3.14 (m, 1H) 2.60-2.84 (m, 4H) 2.42 (s, 3H) 2.16-2.26 (m, 1H) 1.95-2.05 (m, 1H); MS (M+H)+=357.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728031B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-77cd97a9d29b4edcae9d41b13b024132 |
| 출처 메모 | uspto-grants-2010_06 |