HCID 58910028, 화합물 → HCID 22929848, 화합물

HRID 1295926노트

반응식

HRID 1295926 반응식
[Br:1][CH2:2][C:3]1[C:19]([C:20]#[N:21])=[CH:18][C:6]([C:7]([N:9](C)[C:10](=O)OC(C)(C)C)=[O:8])=[C:5]([O:22][CH2:23][CH3:24])[CH:4]=1>ClCCl.FC(F)(F)C(O)=O>[CH3:10][NH:9][C:7](=[O:8])[C:6]1[CH:18]=[C:19]([C:20]#[N:21])[C:3]([CH2:2][Br:1])=[CH:4][C:5]=1[O:22][CH2:23][CH3:24]

참가 물질

4

반응물 1

HCID 58910028HCID 58910028, 화합물

생성물 1

HCID 22929848HCID 22929848, 화합물수율 66.2%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

After dissolving tert-butyl N-[4-(bromomethyl)-5-cyano-2-ethoxybenzoyl]-N-methylcarbamate (39.9 g) in dichloromethane (300 ml), trifluoroacetic acid (50 ml) was added and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated and the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (19.77 g) as a white solid.

후처리

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-7a61708904724355b3082024bbb79ca3
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244730B2

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