Nitric Acid → 4-Bromo-2-tert-butyl-6-nitrophenol

HRID 1295958

반응식

HRID 1295958 반응식
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:7]=1.CCOCC>CCCCCC>[Br:5][C:6]1[CH:11]=[C:10]([N+:1]([O-:4])=[O:2])[C:9]([OH:12])=[C:8]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:7]=1

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 3283Diethyl EtherHCID 970684-Bromo-2-tert-butylphenol

생성물 1

HCID 229297864-Bromo-2-tert-butyl-6-nitrophenol

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Concentrated nitric acid (112 ml) was gradually added dropwise to a solution of 4-bromo-2-(tert-butyl)phenol (485 g) in hexane (3000 ml) while cooling on ice. After stirring for 2 hours at below 20° C., ether (2000 ml) was added and the reaction mixture was washed with water. The organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. Hexane was added to the residue and the precipitated crystals were filtered to yield the title compound (418 g) as yellow crystals.

후처리

  1. temperaturewhile cooling on ice
  2. washthe reaction mixture was washed with water
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. distillationthe solvent was distilled off under reduced pressure
  5. additionHexane was added to the residue
  6. filtrationthe precipitated crystals were filtered

출처 및 근거

ORD 기록
ord-efe05d74fd684ec882f43fd4e5e5b462
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244730B2

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