Ammonium Chloride → 2-[5-Bromo-3-(dimethylamino)-2-methoxyphenyl]-2-propanol

HRID 1295968노트

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HRID 1295968 반응식
[CH3:1][Mg]Br.[Br:4][C:5]1[CH:6]=[C:7]([N:16]([CH3:18])[CH3:17])[C:8]([O:14][CH3:15])=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=1.[Cl-].[NH4+]>CCOCC>[Br:4][C:5]1[CH:6]=[C:7]([N:16]([CH3:18])[CH3:17])[C:8]([O:14][CH3:15])=[C:9]([C:11]([OH:13])([CH3:1])[CH3:12])[CH:10]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 229296931-[5-Bromo-3-(dimethylamino)-2-methoxyphenyl]-1-ethanoneHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 589100492-[5-Bromo-3-(dimethylamino)-2-methoxyphenyl]-2-propanol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

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온도
-70 °C

실험 절차

A solution of methylmagnesium bromide in ether was added to a solution of 1-[5-bromo-3-(dimethylamino)-2-methoxyphenyl]-1-ethanone (4 g) in diethyl ether while stirring at −70° C. After stirring at the same temperature for 30 minutes, saturated aqueous ammonium chloride was added, extraction was performed with ethyl acetate, and the organic layer was washed with brine and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to yield the title compound (3.4 g) as an oil.

후처리

  1. stirringAfter stirring at the same temperature for 30 minutes
  2. extractionextraction
  3. washthe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. distillationThe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-666d40200f8546c88de9a9136b22a148
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244730B2

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