Diethyl Ether → {7-[4-(4-Chloro-phenyl)-4-oxo-butylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester

HRID 1296037노트

반응식

HRID 1296037 반응식
[CH3:1][O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([SH:15])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.Cl[CH2:18][CH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=1)=[O:22].C(=O)([O-])[O-].[Cs+].[Cs+].CCOCC>C(#N)C>[CH3:1][O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15][CH2:18][CH2:19][CH2:20][C:21]([C:23]2[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=2)=[O:22])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 10796Cesium carbonateHCID 27237814,4'-DichlorobutyrophenoneHCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester

생성물 1

HCID 20770865{7-[4-(4-Chloro-phenyl)-4-oxo-butylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Compound 1D (300 mg, 1.26 mmol), 4-chloro-1-(4-chloro-phenyl)-butan-1-one (327 mg, 1.51 mmol), and cesium carbonate (616 mg, 1.89 mmol) in 10 ml anhydrous acetonitrile were stirred at ambient temperature for 72 hours. The reaction was then run through 0.5 g SiO2 eluting with Et2O. The eluant was collected and concentrated to give the title compound, pure enough for subsequent use. MS m/z 419 (M+1).

후처리

  1. customThe eluant was collected
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-156d121ca3e34413933bf59835849e0b
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07244763B2

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