Sodium Iodide → 6-Iodopyridine-3-carboxylic acid

HRID 129604

반응식

HRID 129604 반응식
[I-:1].[Na+].I.Cl[C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1>CC(C)=O>[I:1][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1

참가 물질

5

반응물 3

HCID 5238Sodium Iodide2회HCID 24841Hydrogen iodideHCID 792226-Chloronicotinic acid

생성물 1

HCID 8190626-Iodopyridine-3-carboxylic acid

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 15.962 g ((0.106 mol) of sodium iodide in 51 g (30 ml, 40 mmol) of hydriodic acid were stirred for 5 minutes. To the mixture was added 17.184 g (0.109 mol) of 6-chloro-nicotinic acid and the resulting mixture refluxed at 100-130 C.°C. for 40 hours. The dark brown mixture was then taken up in 300 ml of acetone and stirred to dissolve the excess NaI. The product was collected by suction filtration, rinsed with 100 mL in 1N NaHSO3 and dried to give the title compound as a yellow solid.

후처리

  1. temperaturethe resulting mixture refluxed at 100-130 C.°C
  2. waitfor 40 hours
  3. stirringstirred
  4. filtrationThe product was collected by suction filtration
  5. washrinsed with 100 mL in 1N NaHSO3
  6. customdried

출처 및 근거

ORD 기록
ord-0aaa02c4385242519d249725f36a9c80
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468879

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