Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 2-(p-Chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Methanesulfenyl chloride, trifluoro- | HCID 67900 | — |
| 반응물 | 2-(4-Chlorophenyl)-1h-pyrrole | HCID 272428 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Diethylether water | HCID 21584184 | — |
| 생성물 | 2-(p-Chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole | HCID 18930423 | — |
반응 단계
Trifluoromethylsulfenyl chloride is bubbled into a solution of 2-(p-chlorophenyl)pyrrole (0.5 g, 0.00281 mol) and sodium carbonate (0.36 g, 0.00338 mol) in ether at -30° C. under nitrogen. The reaction mixture is stirred for 1/2 hour and diluted with a water/ether mixture. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title product as a purple solid (0.78 g, mp 34°-39° C.) which is identified by 1HNMR and 13CNMR spectral analyses.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05468877 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-e5932f01af404e01bc526dd5290de688 |
| 출처 메모 | uspto-grants-1995_11 |