Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trichloroacetyl chloride → 5-(p-Chlorophenyl)pyrrol-5-yl trichloromethyl ketone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trichloroacetyl chloride | HCID 6420 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-(4-Chlorophenyl)-1h-pyrrole | HCID 272428 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-(p-Chlorophenyl)pyrrol-5-yl trichloromethyl ketone | HCID 18930394 | 77.7% |
반응 단계
A solution of trichloroacetyl chloride (11.26 g, 0.0619 mol) in ether is treated with a solution of 2-(p-chlorophenyl)pyrrole (10.0 g, 0.0503 mol) in ether, stirred for four hours at room temperature, treated with saturated potassium carbonate solution and diluted with ethyl acetate. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain a yellow solid. The solid is recrystallized from 2-propanol to give the title product as a yellow solid (12.63 g, mp 166°-168° C.) which is identified by 1HNMR spectral analysis.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05468877 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-dff9a2e854e94541aee884d3fb28c0dd |
| 출처 메모 | uspto-grants-1995_11 |