Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 7-Benzyl-8-bromo-3-methylxanthine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione | HCID 1548797 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-Benzyl-8-bromo-3-methylxanthine | HCID 836152 | 89% |
반응 단계
To a stirring suspension of 8-bromo-3-methylxanthine (prepared as for CT13430) (12.25 g, 50.0 mmol) and potassium carbonate (6.91 g, 50.0 mmol) in dimethylformamide (400 ml) was added benzyl bromide (9.24 g, 54.0 mmol). After stirring for 12 hours, the mixture was poured into cold water (680 ml). The precipitate was filtered, washed with water (3×50 ml), ether (3×50 ml) and dried under vacuum to provide 7-benzyl-8-bromo-3-methylxanthine (14.92 g, 89% yield) as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07247630B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-1beba32f5e7e40179fa424f66150ad4c |
| 출처 메모 | uspto-grants-2007_07 |