HCID 60108780, 화합물 → HCID 60108785, 화합물

HRID 1296583노트

반응식

HRID 1296583 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:22]=2[NH:21][CH:20]=[CH:19]3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]3[C:22]=2[NH:21][CH:20]=[CH:19]3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 60108780HCID 60108780, 화합물

생성물 1

HCID 60108785HCID 60108785, 화합물수율 98.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of 4-(1H-indol-7-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester XVII (700 mg, 2.3 mmol) and 10% Pd/C (70 mg) in ethanol (75 mL) was placed under H2 atmosphere on the parr shaker at 50 psi, and was shaken overnight. The reaction mixture was filtered through a plug of celite capped with a glass filter. The filtrate was concentrated to afford (680 mg, 95%) of 4-(1H-indol-7-yl)-piperidine-1-carboxylic acid tert-butyl ester XVIII.

후처리

  1. filtrationThe reaction mixture was filtered through a plug of celite
  2. customcapped with a glass
  3. filtrationfilter
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-2277f9aa378142b4a42af332765685dd
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247651B2

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