Furfuryl Alcohol → 2-(2-Furylmethoxy)-6-(1-Piperazinyl)Pyrazine

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K-t-BuO (1.55 g, 13.8 mmol) was added to a mixture of the product from step 2 above (1.40 g, 7.05 mmol) and 2-furanmethanol (5.3 g, 54 mmol). After being stirred for 7.5 h at 110° C., the mixture was applied onto a bed of silica (16×6 cm). Elution with CHCl3/MeOH (95:5 followed by 90:10) fumished 1.35 g (74%) of the title compound as an oil. HRMS m/z calcd for C13H16N4O2 (M)+ 260.1273, found 260.1276. Anal. (C13H16N4O2) C, H, N.

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