Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 2-[(2,3-Dimethoxybenzyl)Oxy]-6-(1-Piperazinyl)Pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,3-Dimethoxybenzyl alcohol | HCID 79738 | — |
| 반응물 | 2-Chloro-6-[(2,3-dimethoxybenzyl)oxy]pyrazine | HCID 18186927 | — |
| 생성물 | 2-[(2,3-Dimethoxybenzyl)Oxy]-6-(1-Piperazinyl)Pyrazine | HCID 18186895 | — |
반응 단계
The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[(2,3-dimethoxybenzyl)oxy]pyrazine (2.51 g, 8.93 mmol; obtained according to the procedure of example 50, step 1, starting from 2,3-dimethoxybenzyl alcohol), piperazine (2.38 g, 27.7 mmol) and K2CO3 (1.23 g, 8.9 mmol). The yield of the title compound was 1.66 g (56%) which was obtained as an oil. Purity 100% (HPLC). MS m/z 331 (M+H)+. HRMS m/z calcd for C17H22N4O3 (M)+ 330.1692, found 330.1690.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07247633B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-f7fafa3f5593456c8af3818a58481fbd |
| 출처 메모 | uspto-grants-2007_07 |