Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 2-(4-Phenoxybutoxy)-6-(1-Piperazinyl)Pyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Phenoxybutan-1-ol | HCID 219683 | — |
| 반응물 | 2-Chloro-6-(4-phenoxybutoxy)pyrazine | HCID 18186925 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 생성물 | 2-(4-Phenoxybutoxy)-6-(1-Piperazinyl)Pyrazine | HCID 18186776 | — |
반응 단계
The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-(4-phenoxybutoxy)pyrazine (1.99 g, 7.14 mmol; obtained according to the procedure of example 50, step 1, starting from 4-phenoxy-1-butanol*), piperazine (1.84 g, 21.4 mmol) and K2CO3 (0.99 g, 7.14 mmol). The yield of the title compound was 1.52 g (65%) which was obtained as an oil. Purity 100% (HPLC). MS m/z 329 (M+H)+. HRMS m/z calcd for C18H24N4O2 (M)+ 328.1899, found 328.1894. *Prepared by reduction (LiAlH4) of the corresponding acid (cf J. Org. Chem. 1965, 30, 2441-2447; ibid. 1968, 33, 2271-2284).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07247633B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-9c078bf011934db5bb806db1888374ce |
| 출처 메모 | uspto-grants-2007_07 |