N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol-1-yl]acetamide → N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carboxy-1,3-butadienyl)indol-1-yl]acetamide

HRID 129683

반응식

HRID 129683 반응식
[CH3:1][N:2]([CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:3](=[O:29])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:12]=2)[C:7]([CH:22]=CC(OCC)=O)=[CH:6]1.CN(CCC1C=CC=CC=1)C(=O)CC1C=C2C(=CC=1)N(OCC1C=CC=CC=1)C=[C:45]2[CH:59]=[C:60]([C:62]([O:64]CC)=[O:63])C.CN(CCC1C=CC=CC=1)C(=O)CN1C2C(=CC(OCC3C=CC=CC=3)=CC=2)C(C=C(C(O)=O)C=C)=C1>CC(C)=O.CCOCC>[CH3:1][N:2]([CH2:30][CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:3](=[O:29])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:12]=2)[C:7]([CH:22]=[CH:45][CH:59]=[CH:60][C:62]([OH:64])=[O:63])=[CH:6]1

참가 물질

5

반응물 3

HCID 53736924N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol-1-yl]acetamideHCID 53760680N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxy-1,3-butadienyl)indol-1-yl]acetamideHCID 54354901N-methyl-N-phenethyl-2-[1-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-5-yl]acetamide

생성물 1

HCID 53773500N-methyl-N-phenethyl-2-[5-benzyloxy-3-(4-carboxy-1,3-butadienyl)indol-1-yl]acetamide

시약·촉매·용매 1

HCID 21584533Acetone diethylether용매

실험 절차

When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)-indol-1-yl]acetamide in the procedure of Example 23 is replaced with N-methyl-N-phenethyl-2-[1-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-5-yl]acetamide then the product prepared is N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxy-1,3-butadienyl)indol-1-yl]acetamide. (solvent system (acetone/ether) m.p. 189°-190° C.)

후처리

  1. customthe product prepared

출처 및 근거

ORD 기록
ord-bd45b897922d43b99bb2b0c2e44457dd
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468898

연결된 노트

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