Sodium Bicarbonate → HCID 11416722, 화합물

HRID 1296955노트

반응식

HRID 1296955 반응식
C[O:2][C:3]([C:5]1[O:6][C:7]2[C:12]([C:13](=[O:23])[C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)=[CH:11][C:10]([Cl:24])=[C:9]([OH:25])[CH:8]=2)=[O:4].C([O-])(O)=O.[Na+]>CO>[Cl:24][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][C:9]=1[OH:25])[O:6][C:5]([C:3]([OH:4])=[O:2])=[C:14]([C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[C:13]2=[O:23]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 11233736HCID 11233736, 화합물

생성물 1

HCID 11416722HCID 11416722, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

6-Chloro-7-hydroxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid methyl ester was taken up in a 2:1 mixture of sat. NaHCO3 (aq): Methanol and all was heated at 65° C. for 5 hours. The solution was cooled to room temperature and concentrated in vacuo to remove the methanol. The residual aqueous solution was acidified with 1M HCl (aq) and a buff coloured precipitated dropped out of solution. This was collected by vacuum filtration, washed with water and with diethyl ether, to give 6-chloro-7-hydroxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid.

후처리

  1. concentrationconcentrated in vacuo
  2. customto remove the methanol
  3. customa buff coloured precipitated
  4. additiondropped out of solution
  5. filtrationThis was collected by vacuum filtration
  6. washwashed with water and with diethyl ether

출처 및 근거

ORD 기록
ord-bb47942497dc468684708e317f892498
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07247734B2

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