2-Naphthol → Penicillin G

HRID 129703

반응식

HRID 129703 반응식
[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH2:9])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13].[CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)C=C[C:16]=1[OH:25].[OH-].[NH4+]>O>[CH3:11][C:2]1([CH3:1])[S:10][C@@H:5]2[C@H:6]([NH:9][C:16]([CH2:15][C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:25])[C:7](=[O:8])[N:4]2[C@H:3]1[C:12]([OH:14])=[O:13]

참가 물질

5

반응물 3

HCID 86632-NaphtholHCID 14923Ammonium HydroxideHCID 334987-Aminodeacetoxycephalosporanic acid

생성물 1

HCID 5904Penicillin G

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
25 °C

실험 절차

The pH value of a mixture (slurry) of D-PGA.1/2H2SO4 (74.7 g, 0.375 mol), 7-ADCA (21.4 g, 0.10 mol), and 2-naphthol (10.8 g, 0.075 mol, particle size <100 μm) in approximately 300 ml of water was adjusted to 6.7 by addition of 4M ammonium hydroxide. Water was added to 400 ml followed by immobilized E. coli Penicillin G acylase prepared as described above (50 g on dry basis suspended in water to a total of 100 ml), and the mixture was stirred at 25° C.

후처리

  1. customon dry basis

출처 및 근거

ORD 기록
ord-2576228db0324c0b98d3a4546f045b56
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05470717

연결된 노트

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