Water → 2-Methyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid

HRID 129726

반응식

HRID 129726 반응식
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=O)[CH3:2].[NH2:10][C@H:11]([C:14]([OH:16])=[O:15])[CH2:12][SH:13].O>C(O)C>[CH3:2][C:1]1([C:4]2[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:10][CH:11]([C:14]([OH:16])=[O:15])[CH2:12][S:13]1

참가 물질

5

반응물 3

HCID 962WaterHCID 5862L-(+)-CysteineHCID 95893-Acetylpyridine

생성물 1

HCID 148815392-Methyl-2-(3-pyridyl)thiazolidine-4-carboxylic acid수율 37.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3.63 g of 3-acetylpyridine, 3.63 g of L-cysteine, 25 ml of water and 25 ml of ethanol was refluxed for 24 hours. The reaction mixture was concentrated under reduced pressure, isopropanol was added to the residue, and the resultant powder was collected by filtration. Ethanol was added to the powder, the insoluble matter was filtered off, and the filtrate was concentrated to dryness. The residue was dissolved in water and adjusted to pH 6 by addition of diluted hydrochloric acid under ice cooling and stirring, and the resultant powder was collected by filtration, washed with ethanol and dried to give 2.54 g of 2-methyl-2-(3-pyridyl)thiazolidine-4- carboxylic acid.

후처리

  1. temperaturewas refluxed for 24 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure, isopropanol
  3. additionwas added to the residue
  4. filtrationthe resultant powder was collected by filtration
  5. additionEthanol was added to the powder
  6. filtrationthe insoluble matter was filtered off
  7. concentrationthe filtrate was concentrated to dryness
  8. dissolutionThe residue was dissolved in water
  9. additionadjusted to pH 6 by addition of diluted hydrochloric acid under ice cooling
  10. filtrationthe resultant powder was collected by filtration
  11. washwashed with ethanol
  12. customdried

출처 및 근거

ORD 기록
ord-d9856abc93b2451cbf7466012acd1937
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05470851

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