N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine → N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-amine
반응식
C(O[C@H]1CNC[C@H]1NC1C(CC)=NC(C2C(C)=NC(OC)=CC=2)=C(CC)N=1)C.[CH2:29]([C:31]1[C:32]([NH:51][C@H:52]2[C@@H:56]([O:57][CH2:58][CH3:59])[CH2:55][N:54](C(OCC3C=CC=CC=3)=O)[CH2:53]2)=[N:33][C:34]([CH2:49][CH3:50])=[C:35]([C:37]2[C:38]([C:45]([F:48])([F:47])[F:46])=[N:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=2)[N:36]=1)[CH3:30]>>[CH2:58]([O:57][C@H:56]1[CH2:55][NH:54][CH2:53][C@H:52]1[NH:51][C:32]1[C:31]([CH2:29][CH3:30])=[N:36][C:35]([C:37]2[C:38]([C:45]([F:48])([F:47])[F:46])=[N:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=2)=[C:34]([CH2:49][CH3:50])[N:33]=1)[CH3:59]참가 물질
3
반응물 2
생성물 1
실험 절차
Following the procedure for the preparation of N-[(3R,4S)-4-ethoxypyrrolidin-3-yl]-3,6-diethyl-5-(6-methoxy-2-methylpyridin-3-yl)pyrazin-2-amine but substituting benzyl (3R,4S)-3-({3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]pyrazin-2-yl}amino)-4-ethoxypyrrolidine-1-carboxylate provided the title compound as an amber oil. 1H NMR (CDCl3) δ 1.13, 1.28, 2.41, 2.69, 3.14, 3.37, 3.51, 3.66˜3.75, 4.04, 4.16, 4.69, 5.29, 6.96, 7.54; IR (liq.) 2975 (s), 2417 (b), 2177 (b), 2029 (w), 1923 (w), 1609 (s), 1565 (s), 1479 (s), 1400 (s), 1341 (s), 1278 (s), 1239 (s), 1192 (s), 1177 (s), 1138 (s) cm−1.
출처 및 근거
- ORD 기록
- ord-824378dbbcc240f5b9fd37434ee5084c
- 출처 데이터셋
- uspto-grants-2007_07
- 특허 번호
- US07250418B2
반응 노트
불러오는 중…